VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Enzymatic mechanisms of inhibition of peroxidative oxidation in different regions of rat brain

   
Gerasimov A.M., Koroleva L.A., Brusov O.S., Olfer'ev A.M., Antonenkov V.D., Panchenko L.F.
PubMed Id: 1030882
Year: 1976  Volume: 22  Issue: 1  Pages: 89-94
Activities of catalase, superoxide dismutase, glutathione peroxidase were studied in the cortex, cerebellul and stem of rat brain. The presence of glutathione: dehydroascorbate reductase was observed in rat brain. The highest levels of catalase, superoxide dismutase and the lowest levels of glutathione peroxidase, glutathione: dehydroascorbate reductase were found in the stem; the level of glutathione peroxidase was highest in the cerebellum. The significant part (30--40%) of thiol containing substances was bound with proteins as mixed disulfides. The role of the enzymes studied in regulation of free-radical processes and of the content of peroxides in brain tissue is discussed.
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Gerasimov, A. M., Koroleva, L. A., Brusov, O. S., Olfer'ev, A. M., Antonenkov, V. D., Panchenko, L. F. (1976). Enzymatic mechanisms of inhibition of peroxidative oxidation in different regions of rat brain. Voprosy Meditsinskoi Khimii, 22(1), 89-94.
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