VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Zonal distribution of haptoglobin and ceruloplasmin synthesis in the liver

   
Volkova Z.I.
PubMed Id: 1030885
Year: 1976  Volume: 22  Issue: 2  Pages: 171-176
Effect of hepatotoxic agents (carbon tetrachloride and dimethyl nitrosamine) on the rate of the haptoglobin and ceruloplasmin synthesis in liver tissue was studied. In impairment of hepatocytes in the central zone of liver lobes, the distinct decrease in content of haptoglobin was shown to occur with a simultaneous increase in content of ceruloplasmin in blood serum. When parenchyma of the central zone of liver lobes regenerated, the haptoglobin content tended to normalization. The data obtained suggest that the synthesis of haptoglobin and ceruloplasmin is carried out in different zones of liver tissue lobes: haptoglobin is mainly found in the central zone and ceruloplasmin -- in the peripheral one.
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Volkova Z.I. (1976) Voprosy meditsinskoi khimii, 22(2), 171-176.
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