VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Study of the active calcium transport mechanisms in uterine smooth muscle

   
Kurskiĭ M.D., Fedorov A.N., Iakovenko A.P.
PubMed Id: 140526
Year: 1976  Volume: 22  Issue: 2  Pages: 223-227
Calcium ions were shown to be actively accumulated in mitochondrial and microsomal fractions of uterine smooth muscle of rabbit and cattle. In presence of magnesium ions Ca2+ (10-6-10-4 M) activate microsomal ATPase from cattle uterus. The rate of formation and dissociation of the intermediate phosphorylated substance of Mg2+, Ca2+-ATPase was found to be lower in microsomes of smooth muscles than in sarcoplasmic reticulum of sceletal muscles. Serotonine (concentration 10-6 M) increased the dissociation of the intermediate phosphorylated substance from microsomes of uterine smooth muscle and decreased their capacity to bind Ca2+. At the same concentration serotonine inhibited the ATP-dependent accumulation of 45Ca by microsomes of uterine smooth muscle.
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Kurskiĭ, M. D., Fedorov, A. N., Iakovenko, A. P. (1976). Study of the active calcium transport mechanisms in uterine smooth muscle. Voprosy Meditsinskoi Khimii, 22(2), 223-227.
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