VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Regulation of L-asparaginase biosynthesis in mutants of Bacillus mesentericus 43A, poorly growing in the presence of aspartic acid

   
Eremenko V.V., Mardashev S.R., Tiul'panova E.S., Evseev L.P.
PubMed Id: 1025895
Year: 1976  Volume: 22  Issue: 3  Pages: 334-338
Biosynthesis of L-asparaginase (EC 3.5.1.1) was inhibited in the growing culture of Bac. mesentericus 43A on addition of L-aspartic acid (20 mM). My treatment with methyl nitrosourea (2 mg/ml) mutants were obtained, which grew poorly on aspartic acid used as the only source of carbon and nitrogen. The aspartic acid did not repress the asparaginase biosynthesis in 8 strains, found between the mutants. In six of these mutants the asparaginase biosynthesis was inhibited by means of the type of catabolite repression. The data obtained suggest that in Bac. mesentericus 43A the asparaginase biosynthesis is controlled more likely by two independent mechanisms: 1) specific repression with aspartic acid as an end product and 2) catabolite repression.
Download PDF:  
Citation:

Eremenko, V. V., Mardashev, S. R., Tiul'panova, E. S., Evseev, L. P. (1976). Regulation of L-asparaginase biosynthesis in mutants of Bacillus mesentericus 43A, poorly growing in the presence of aspartic acid. Voprosy Meditsinskoi Khimii, 22(3), 334-338.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►