VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of hemorrhagic shock on catecholamine metabolism in the brain

   
Avakian O.M., Shirinian E.A.
PubMed Id: 1030895
Year: 1976  Volume: 22  Issue: 3  Pages: 377-380
Content of adrenaline, noradrenaline, dopamine, DOPA and normethanephrine was estimated by means of the hydroxyindole method in brain tissue and hypothalamic region of rats subjected to hemorrhagic shock (loss of 3% of blood during 20 min) within 15 min, 2, 24 and 72 hrs. At the first day after the hemorrhage an increase in content of adrenaline and a distinct decrease in content of noradrenaline were observed in hypothalamic region, although the biosynthesis the neurotransmitters was not inhibited. Then, the noradrenaline concentration was normalized but the content of its precursors was decreased. In brain a constant posthemorrhagic increase in content of dopamine and the phase alterations in patterns of the catecholamine metabolism were observed: an initial decrease in synthesis and turnover of noradrenaline followed by its increased metabolism.
Download PDF:
Citation:

Avakian, O. M., Shirinian, E. A. (1976). Effect of hemorrhagic shock on catecholamine metabolism in the brain. Voprosy meditsinskoi khimii, 22(3), 377-380.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)