VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of acetylsalicylic and 2,3-dihydroxybenzoic acids on liver mitochondrial respiration in rats

   
Cherkasskaia M.D., Iasaĭtis A.A.
PubMed Id: 1027226
Year: 1976  Volume: 22  Issue: 4  Pages: 443-448
Acetylsalicylate (2-5 mM) inhibited phosphorylating (condition III) and uncoupled respiration of rat liver mitochondria in vitro, when succinate and glutamate were used as substrates of oxidation. Lower concentrations of acetylsalicylate did not cause the uncoupling effect. Antirheumatic drug 2,3-dihydroxybenzoate activated the phosphorylation in mitochondria, if it was added up to concentrations of 0.5-5.0 mM for succinate and 0.5 mM for glutamate. An increase of 2,3-dihydroxybenzoate concentration was accompanied by gradual inhibition of phosphorylating and uncoupled oxidation of succinate; activation of the respiration was completely abolished by addition of ADP, DNP and 2,3-dihydroxybenzoate (20 mM). The data obtained suggest that the uncoupling effect of salicylate, which is formed by hydrolysis of acetylsalicylate in the organism, might be responsible for the toxic effect of the latter.
Download PDF:  
Citation:

Cherkasskaia, M. D., Iasaĭtis, A. A. (1976). Effect of acetylsalicylic and 2,3-dihydroxybenzoic acids on liver mitochondrial respiration in rats. Voprosy Meditsinskoi Khimii, 22(4), 443-448.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►