VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of Central Asian cobra (Naja naja oxiana) venom on the biosynthesis of nucleic acids and protein in animal cells

   
Turakulov I.Kh., Khalikov S.K., Rakhimov M.M., Sorokin V.M.
PubMed Id: 1027229
Year: 1976  Volume: 22  Issue: 4  Pages: 462-465
Cobra poison at a dose of 4 microng/kg of body weight intensified the 3H-thimidine incorporation into DNA of mice liver tissue; 20-40 microng/kg of the poison inhibited the incorporation. Single intraperitoneal administration of high doses of cobra poison (50-150 microng/kg) decreased the incorporation of 14C-thimidine into DNA 1.2-1.9-fold. Little doses of the poison increased the incorporation of 14C-hydrolysate of Chlorella protein into proteins of liver cells and the high doses inhibited this process. Microdoses of cobra poison caused a distinct increase in weight of experimental mice.
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Turakulov, I. Kh., Khalikov, S. K., Rakhimov, M. M., Sorokin, V. M. (1976). Effect of Central Asian cobra (Naja naja oxiana) venom on the biosynthesis of nucleic acids and protein in animal cells. Voprosy Meditsinskoi Khimii, 22(4), 462-465.
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