VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Regulation of peroxidation of mitochondrial membrane lipids initiated by Fe2+ ions by antoxidants of the 1,4-dihydropyridine series in experiments in vitro

   
Dubur G.Ya., Velena A.Kh., Gukasov V.M., Vladimirov I.A.
PubMed Id: 1014479
Year: 1976  Volume: 22  Issue: 5  Pages: 665-672
Effect of antioxidants on the rate of free radical peroxidation was studied in mitochondria in presence of Fe2+. For this purpose derivatives of 1,4-dihydroxypyridine, their heteroaromatic analogues, NAD-H+ and butyl hydroxytoluene (35 substances) were tested in the system by chemoluminescence. Several 1,4-dihydroxypyridine derivatives were found to be effective reagents in the system and could be compared by the activity with the recognized synthetic antioxidant butyl hydroxytoluene.
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Dubur, G. Ya., Velena, A. Kh., Gukasov, V. M., Vladimirov, I. A. (1976). Regulation of peroxidation of mitochondrial membrane lipids initiated by Fe2+ ions by antoxidants of the 1,4-dihydropyridine series in experiments in vitro. Voprosy meditsinskoi khimii, 22(5), 665-672.
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