VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

In vitro metabolism of ubiquinone and ubichromenol in the livers of rats with avitaminosis E during individual and combined addition of alphalphalpha-tocopherol and phenylalanine

   
Donchenko G.V., Chernukhina L.A., Zolotashko O.M., Teplitskaia L.Yu.
PubMed Id: 1014483
Year: 1976  Volume: 22  Issue: 5  Pages: 691-696
A maximal incorporation of 2-14C-acetate into ubiquinone and ubichromenol was found within 3 hrs if liver tissue homogenate of E-avitaminous rats was incubated for 4 hrs. Phenylalanine, added to the mixture, stimulated the biosynthesis of ubiquinone and ubichromenol in the liver tissue preparations. alpha-Tocopherol caused an increase in biosynthesis of ubiquinone and a decrease in the rate of ubichromenol biosynthesis within 1 hr and 3 hrs of incubation in vitro. The combined addition of phenylalanine and alpha-tocopherol, almost without exceptions, increased the effect of alpha-tocopherol on biosynthesis of the substances studied. Interrelationship is discussed between vitamin E and ubiquinone and ubichromenol biosynthesis.
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Donchenko, G. V., Chernukhina, L. A., Zolotashko, O. M., Teplitskaia, L. Yu. (1976). In vitro metabolism of ubiquinone and ubichromenol in the livers of rats with avitaminosis E during individual and combined addition of alphalphalpha-tocopherol and phenylalanine. Voprosy Meditsinskoi Khimii, 22(5), 691-696.
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