VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Method of determining the intregral activity of catechol-O-methyltransferase in the human body in vivo

   
Kulinskiĭ V.I., Oloviannikova R.Ya.
PubMed Id: 1014485
Year: 1976  Volume: 22  Issue: 5  Pages: 708-712
A method is developed for estimation of the catecholamine-O-methyl transferase activity in human organism by excretion with urine of unmetabolized isadrine (N-isopropyl noreadrenaline) after loading. Excretion of isadrine was increased both after administration of apomorphine, which is one of the inhibitors of the enzyme catecholamine-O-methyl transferase, and in cases of liver tissue pathology. It is known that the maximal activity of catecholamine-O-methyl transferase is the highest in liver tissue. Imipramine (an inhibitor of uptake of catecholamine) did not inhibit the activity of cafecholamine-O-methyl transferase as estimated by the present method.
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Kulinskiĭ, V. I., Oloviannikova, R. Ya. (1976). Method of determining the intregral activity of catechol-O-methyltransferase in the human body in vivo. Voprosy Meditsinskoi Khimii, 22(5), 708-712.
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