VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Antivitamin activity of thiaminase from freshwater bicuspid molluscs after parenteral administration of the enzyme to albino mice

   
Puzach S.S., Ostrovskiĭ I.M.
PubMed Id: 1027249
Year: 1976  Volume: 22  Issue: 6  Pages: 769-773
Thiaminase from bicuspid mollusc, after a single administration into mice (25 or 50 un, subcutaneously), caused a decrease in the activity of transketolase and alpha-ketoglutaric acid dehydrogenase in the animal tissues within 3 hrs. The maximal antivitaminous effect of thiaminase was manifested within 2-5 days and slightly decreased within 7 days (at a dose of 25 un). Amount of thiamin was decreased in mice liver tissue from 6.54+/-0.36 mcg/g to 4.84+/-0.23 mcg/g within the second day after the thiaminase administration. Transketolase and alpha-ketoglutarate dehydrogenase from liver and kidney were more sensitive to the antivitaminous effect of thiaminase. General condition of the animals was not altered by parenteral administration of thiaminase during a week. Thiaminase may be recommended for modelling of thiamin deficiency in animals maintained at conventional diets.
Download PDF:  
Citation:

Puzach, S. S., Ostrovskiĭ, I. M. (1976). Antivitamin activity of thiaminase from freshwater bicuspid molluscs after parenteral administration of the enzyme to albino mice. Voprosy Meditsinskoi Khimii, 22(6), 769-773.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►