VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Cation permeability of liver mitochondrial membranes during Ca+-dependent anoxic damage in vitro

   
Bragin E.O., Sorokovoi V.I., Chernikov V.P., Kogan E.M., Vladimirov Iu.A.
PubMed Id: 888394
Year: 1977  Volume: 23  Issue: 3  Pages: 297-302
Ca2+ ions are responsible for impairment of oxidative phosphorylation in rat liver mitochondria under anoxia in vitro. The decrease in this function is due to inhibition of electron transport over respiratory chain and to uncoupling. The increase in membrane permeability for H+, K+ and Na+ was observed on incubation of mitochondria under anoxic condition together with Ca2+. Uncoupling of phosphorylation depends on the increased permeability of the membranes for H+. The increased permeability of membranes for Na+ and K+ under energy liberation and in presence of penetrating anions led to active swelling of organelles and to secondary (osmotic) impairment. Ca2+-activated mitochondrial phospholipase A2 appears to participate in the organelle impairment under anoxia.
Download PDF:  
Citation:

Bragin, E. O., Sorokovoi, V. I., Chernikov, V. P., Kogan, E. M., Vladimirov, Iu. A. (1977). Cation permeability of liver mitochondrial membranes during Ca+-dependent anoxic damage in vitro. Voprosy Meditsinskoi Khimii, 23(3), 297-302.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►