Accumulation of lipids, including phospholipids, in lungs was accompanied by a proliferative-cellular reaction. The proliferation of cells was caused by accumulation of lipids. One of possible mechanisms of interrelation between lipids and collagen synthesis was as follows: in silicosis degradation of macrophages was accompanied by secretion into the medium of phospholipids, which inhibited free radical oxidation; in this case the decreased formation of cytotoxic products caused the cell proliferation, including fibroblasts, which produced collagen. The importance of lipids in collagen formation was corroborated: by accumulation of lipids, which preceded the hydroxyproline increase (scleroproteins, collagen), by development of the proliferative-cellular reaction together with the higher phospholipid-hydroxyproline level as compared with control, by formation of earlier sclerosis of silicotic nodes in 'condensed' silicosis with the simultaneous increase in absolute content of phospholipids and total lipids. This role of lipids was also supported by the observed correlation between the absolute contents of scleroproteins and lipids within all steps of 'quartz' silicosis development.
Belobragina G.V. и др., Interrelationships between lipids and scleroproteins in silicosis caused by crystalline and condensed modifications of silicon //Voprosy meditsinskoi khimii.- 1977. -Т.23. -№ 4. С. 453-458.
Belobragina G.V. и др., "Interrelationships between lipids and scleroproteins in silicosis caused by crystalline and condensed modifications of silicon." Voprosy meditsinskoi khimii 23.4 (1977): 453-458.
Belobragina G.V., El'nichnykh L.N. (1977). Interrelationships between lipids and scleroproteins in silicosis caused by crystalline and condensed modifications of silicon. Voprosy meditsinskoi khimii, 23(4), 453-458.