VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Disorders in the phenylalanine hydroxylase system of the liver in alcoholism

   
Shaposhnikov A.M., Skachkov M.M.
PubMed Id: 919373
Year: 1977  Volume: 23  Issue: 4  Pages: 495-499
Metabolism of phenylalanine and tyrosine was impaired in chronic alcoholism as shown by an increase in concentration of phenylalanine and by a decrease in content of tyrosine in blood serum as well as by elevated urinary excretion of phenylalanine and phenylpyruvic acid and by decreased excretion of homogentisinic acid. Loading with L-phenylalanine made these impairments more distinct. The data obtained suggest that the activity of phenylalanine hydroxylase system from liver tissue is decreased in chronic alcoholism. The most distinct impairment in phenylalanine metabolism was observed in alcohol withdrawal syndrom. The decrease in the activity of phenylalanine hydroxylase system may cause an accumulation of phenylalanine and its metabolites in brain tissue at well as an impairment of biogenic amines metabolism in central nervous system.
Download PDF:  
Citation:

Shaposhnikov, A. M., Skachkov, M. M. (1977). Disorders in the phenylalanine hydroxylase system of the liver in alcoholism. Voprosy Meditsinskoi Khimii, 23(4), 495-499.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►