VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of Ca2+ ions on the pyruvate kinase isoenzymes from rabbit kidney cortex

   
Il'in V.S., Kozhevnikova K.A.
PubMed Id: 595501
Year: 1977  Volume: 23  Issue: 5  Pages: 653-657
Ca2 ions showed the various effect on isoenzymes of pyruvate kinase from rabbit kidney cortex. Ca2 activated the 'L' type of pyruvate kinase at low concentrations of PEP and inhibited -- at high concentrations of the latter. 'M2' type of pyruvate kinase was inhibited by Ca2 under all the conditions studied. In presence of Ca2+ the activating effect of PDP on 'L' and 'M2' types of pyruvate kinase was absent; the inhibitory action of ATP on the 'M' type of pyruvate kinase was increased at all the concentrations above 1.3 mM. The effect of Ca2+ on the pyruvate kinase isoenzymes depended on content of Mg2+ in the medium.
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Il'in, V. S., Kozhevnikova, K. A. (1977). Effect of Ca2+ ions on the pyruvate kinase isoenzymes from rabbit kidney cortex. Voprosy Meditsinskoi Khimii, 23(5), 653-657.
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