VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Pantothenate metabolism in the rat liver and its regulation

   
Rozanov A.Ya., Kirilenko O.A., Savchenko S.N., Stepanova L.N., Agafonova N.E.
PubMed Id: 595503
Year: 1977  Volume: 23  Issue: 5  Pages: 661-667
Pantothenate, penetrating the liver tissue after intraperitoneal administration into young rats at a dose 100 mumole/kg was metabolized to unidentified substances within 15-30 min without accumulation of 4-phosphopantothenate. Within subsequent 2-4 hrs period pantothenate, 4-phosphopantothenate, CoA and considerably higher amounts of the unidentified metabolites (apparently symmetric and mixed (disulphides) were simultaneously accumulated in liver tissue; the latter substances determined the subsequent prolonged and essential elevation in content of CoA in the liver tissue. The phase dynamics of accumulation in liver tissue of the administered pantothenate is due to its recirculation from intestine and to alteration in the activity of pantothenate metabolizing enzymes, particularly those, which catalyze the reactions of thiodisulphide metabolism.
Download PDF:  
Citation:

Rozanov, A. Ya., Kirilenko, O. A., Savchenko, S. N., Stepanova, L. N., Agafonova, N. E. (1977). Pantothenate metabolism in the rat liver and its regulation. Voprosy Meditsinskoi Khimii, 23(5), 661-667.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►