VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Depression of rat liver acetyl-CoA-carboxylase activity by salicylate and other compounds

   
Denisenko T.V., Poliakova E.D.
PubMed Id: 22955
Year: 1977  Volume: 23  Issue: 5  Pages: 667-672
Two intraperitoneal injections of salicylate at a dose of 250 mg/kg of body weight led to decrease in the acetyl-CoA-carboxylase activity in liver soluble fraction (140000xg) more than by 60%. Salicylate in concentrations 10(-4) and 10(-2) M inhibited the enzyme from rat liver soluble fraction by 25% and 80%, respectively, in vitro: it was found to be as effective inhibitor as kynurenate and clofibrate. Derivatives of salicylate -- acetyl salicylate and salicyl amide also showed this inhibitory effect, but their action was less disinct as compared with salicylate. 2-phenyl-3-methyl-hydroxypentanic and 2,3-diphenyl-3-hydroxypentanic acids (derivatives of deoxymevalonic acid) demonstrated the strong inhibitory effect on acetyl-CoA-carboxylase, comparable to the action of salicylate. The effect of salicylate on the reaction of carboxylation was not related to competition for acetyl-CoA (formation of acetyl salicylate), to interaction with biotin and to allosteric reaction with acetyl-CoA-carboxylase. Possible mechanisms of the salicylate effect on the enzyme activity are discussed.
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Denisenko, T. V., Poliakova, E. D. (1977). Depression of rat liver acetyl-CoA-carboxylase activity by salicylate and other compounds. Voprosy Meditsinskoi Khimii, 23(5), 667-672.
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