VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Role of phospholipase A2 in anoxic injury to the energy-dependent functions of the mitochondria

   
Bragin E.O., Dergunov A.D., Neugodova G.L., Sorokovoj V.I., Vladimirov Yu.A.
PubMed Id: 413264
Year: 1977  Volume: 23  Issue: 5  Pages: 673-676
An increase in concentration of free fatty acids was observed simultaneously with a decrease in energy dependent functions of mitochondria (oxidative phosphorylation and Ca2+-accumulating ability) after their preincubation under anoxic conditions in vitro with Ca2+ ions (11-14 nmol/mg of mitochondrial protein). Impairment of mitochondria and accumulation of fatty acids were prevented by inhibitors of phospholipase A2 from mitochondria. The anoxic impairment of mitochondria appears to be caused by Ca2+-activated phospholipase A2.
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Citation:

Bragin, E. O., Dergunov, A. D., Neugodova, G. L., Sorokovoj, V. I., Vladimirov, Yu. A. (1977). Role of phospholipase A2 in anoxic injury to the energy-dependent functions of the mitochondria. Voprosy Meditsinskoi Khimii, 23(5), 673-676.
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