VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of 1-D-ribofuranosyl-1,2,4-triazol-3-carboxamide on the synthesis of cellular macromolecules in cell culture

   
Pushkarskaia N.L., Dikij V.V., Galegov G.A.
PubMed Id: 664489
Year: 1978  Volume: 24  Issue: 1  Pages: 84-87
Ribovirine (I-D-ribofuranosyl-1,2,4-triazol-3-carboxamide) possesses the distinct antiviral action against many strains of RNA- and DNA-containing viruses. Data on the effect of ribovirine on the synthesis of cellular macromolecules are presented. After treatment with ribovirine the synthesis of cellular RNA was inhibited by 80-85%. The synthesis of DNA and proteins was decreased less distinctly. The experiments were carried out using the primary tryptic-treated culture of fibroblasts from chicken embryos.
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Pushkarskaia, N. L., Dikij, V. V., Galegov, G. A. (1978). Effect of 1-D-ribofuranosyl-1,2,4-triazol-3-carboxamide on the synthesis of cellular macromolecules in cell culture. Voprosy meditsinskoi khimii, 24(1), 84-87.
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