VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Comparative lecithin-cholesterol-acyltransferase deficiency in the blood of newborn infants. Comparison of the esterifying activity of neonatal and maternal blood

   
Nikiforova A.A., Chistiakova A.M., Matveev I.I., Teriukova N.P., Arkhipov O.P., Kliorin A.I., Klimov A.N.
PubMed Id: 208296
Year: 1978  Volume: 24  Issue: 1  Pages: 87-92
On the basis of data obtained in studies on the accumulation of cholesterol in erythrocytes of newlorns, the hypothesis is advanced on the deficiency of lecithin-cholesterol-acetyl transferase (LCAT) in the newborn children. A decrease in the rate of the LCAT-reaction was shown in funic blood using the specially developed system "LP-infranatante", the constituents of which were isolated from blood plasma of both newborns and of their mothers by ultracentrifugation at a density 1.21 g/ml and 40.000 rpm. The following factors were considered as possible determinants of the decrease in the rate of cholesterol esterification in blood plasma of newborns: 1) insufficiency in LCAT, 2) alteration in the composition of the substrate lipoproteins (lipoproteins of high density).
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Nikiforova, A. A., Chistiakova, A. M., Matveev, I. I., Teriukova, N. P., Arkhipov, O. P., Kliorin, A. I., Klimov, A. N. (1978). Comparative lecithin-cholesterol-acyltransferase deficiency in the blood of newborn infants. Comparison of the esterifying activity of neonatal and maternal blood. Voprosy Meditsinskoi Khimii, 24(1), 87-92.
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