VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Characteristics of estradiol-receptor interaction in the cytosol of the human Fallopian tubes

   
Fanchenko N.D., Minina L.S., Shchedrina R.N.
PubMed Id: 664445
Year: 1978  Volume: 24  Issue: 2  Pages: 198-201
Physico-chemical parameters (the rate constants of association and dissociation, half life of the estradiol-receptor complex, equilibrium constant, alteration of free energy of the bond) of estradiol-receptor interaction were studied in cytosole in human Fallopian tubes. Amounts of the cytoplasmic binding sites per cell were estimated. Specific interaction of the tube cytosole receptor system with 13 substances was examined. Steroid-receptor reaction has mainly been determined by presence of hydroxyl groups in the 3-d phenol and 17beta-positions. Nearest surroundings at the hydroxyls was also important for manifestation of the affinity of the steroids to the system studied.
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Fanchenko, N. D., Minina, L. S., Shchedrina, R. N. (1978). Characteristics of estradiol-receptor interaction in the cytosol of the human Fallopian tubes. Voprosy Meditsinskoi Khimii, 24(2), 198-201.
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