VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Importance of the fibrinogen-heparin complex in the fibrinolytic activity of the blood euglobulin fraction after the intravenous administration of thrombin or plasmin

   
Kudriashov B.A., Liapina L.A., Ul'ianov A.M.
PubMed Id: 149422
Year: 1978  Volume: 24  Issue: 2  Pages: 255-260
Intravenous administration of plasmin as distinct from thrombin inhibited or did not provide a secretion of endogenous heparin into circulation. In these conditions non-enzymatic fibrinolysis was not observed both in fraction of euglobulins and in fibrinogen-heparin complex, isolated from euglobulins, due to insufficiency of heparin. Exogenous heparin, injected into circulation or added to corresponding fractions, enabled to produce the active heparin complexes. About 70% of total fibrinolytic activity was due to fibrinogen-heparin complex in euglobulin fraction of blood plasma, isolated from blood of animals intravenously administered with thrombin.
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Kudriashov, B. A., Liapina, L. A., Ul'ianov, A. M. (1978). Importance of the fibrinogen-heparin complex in the fibrinolytic activity of the blood euglobulin fraction after the intravenous administration of thrombin or plasmin. Voprosy Meditsinskoi Khimii, 24(2), 255-260.
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