VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Change in the intracellular ATP pool in rat tissues after ATP administration

   
Atabekova G.A., Koshcheenko N.N., Romantsev E.F.
PubMed Id: 664471
Year: 1978  Volume: 24  Issue: 3  Pages: 401-404
Concentration of ATP in thymus, spleen, blood and liver tissues of intact rats constituted 84.6 +/- 9.3, 62.3 +/- 12.8, 18.7 +/- 3.9 and 103 +/- 23.8 mg% per 1 g of tissue, respectively. Intramuscular administration of ATP at a dose 350 mg/kg caused wave-shaped alterations in ATP content in rat spleen and liver tissues. Concentration of the nucleotide tend to increase in blood within the period of examination (4 days). Alterations observed in the pool of ATP in tissues studied appear to be due to the effect of the dephosphorylation products of the ATP administered (adenosine, probably) on intracellular metabolism of adenylicnucleotides, particularly, on the metabolism of ATP.
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Atabekova, G. A., Koshcheenko, N. N., Romantsev, E. F. (1978). Change in the intracellular ATP pool in rat tissues after ATP administration. Voprosy Meditsinskoi Khimii, 24(3), 401-404.
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