VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Hepatic energy metabolism disorders in emotionally-painful stress and prevention of these disorders with sodium gamma-hydroxybutyrate

   
Meerson F.Z., Pavlova V.I., Kamilov F.Kh., Iakushev V.S.
PubMed Id: 569922
Year: 1978  Volume: 24  Issue: 6  Pages: 774-779
Content and biosynthesis of glycogen in rat liver tissue as well as transition of 14C from main substrates of tricarboxylic acid cycle to CO2, examined in liver slices, were studied under conditions of stress caused by pain and emotion. The stress was accompanied by mobilization of the glycogen deposits; glycogen synthesis in liver tissue and oxidation of pyruvate, asparate succinate or alpha-ketoglutarate in tricarboxylic acid cycle were inhibited. At the same time, the stress was accompanied by ulcerous impairments of gastric mucosa. The phenomena observed appear to be due to increased activity of adrenergic and sympathoadrenal systems. Prior to the stress administration of sodium gamma-hydroxybutyrate, which activates the inhibitory GHB-ergic system of brain, prevented distinctly the impairments found.
Download PDF:  
Citation:

Meerson, F. Z., Pavlova, V. I., Kamilov, F. Kh., Iakushev, V. S. (1978). Hepatic energy metabolism disorders in emotionally-painful stress and prevention of these disorders with sodium gamma-hydroxybutyrate. Voprosy Meditsinskoi Khimii, 24(6), 774-779.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►