VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Hypolipidemic activity of substances structurally close to penphenone in rats and mice

   
Polikarpova L.I., Reznik S.E., Ryzhenkov V.V., Khechinashvili G.G., Petrova L.A.
PubMed Id: 216145
Year: 1978  Volume: 24  Issue: 6  Pages: 835-839
Effect of substances, structurally related to penphenone (2-phenyl-3-methyl-3-hydroxypentanic acid sodium salt), was studied on the main patterns of lipid metabolism in blood of rats and mice, as well as on lipoprotein spectra of rat blood serum. All the compounds studied exhibited hypolipidemic effect, decreasing concentration of total cholesterol, cholesterol of alpha-lipoproteins and triglycerides in rat blood. The effect was less distinct in mice. 2-phenyl-3,4-dimethyl-3-hydroxypentanic acid sodium salt possessed the most pronounced hypolipidemic effect. A decrease in content of beta-and pre-beta-lipoproteins as well as of alpha-lipoproteins was observed after electrophoretic separation of blood serum lipoproteins in polyacrylamide gel in animals treated with the compound.
Download PDF:  
Citation:

Polikarpova, L. I., Reznik, S. E., Ryzhenkov, V. V., Khechinashvili, G. G., Petrova, L. A. (1978). Hypolipidemic activity of substances structurally close to penphenone in rats and mice. Voprosy Meditsinskoi Khimii, 24(6), 835-839.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)