VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

mRNA degradation in membrane-bound and free polyribosomes in rat liver cells after exposure to actinomycin D and cycloheximide

   
Arbusov V.A.
PubMed Id: 425372
Year: 1979  Volume: 25  Issue: 1  Pages: 62-67
Actinomycin D caused degradation of mRNA both in membrane-bound and in free polyribosomes from rat liver cells. The rate of mRNA destruction was distinctly higher in free polyribosomes, than in membrane-bound ones. Cycloheximide inhibited the mRNA destruction in both types of polyribosomes. At the same time, the stabilizing effect of cycloheximide on mRNA was less distinct in free polyribosomes. A decrease in specific radioactivity of mRNA from membrane-bound and free polyribosomes was observed after prolonged pretreatment with actinomycin D. The specific radioactivity of mRNA from polyribosomes of both types was not altered after simultaneous administration of actinomycin D and cycloheximide into rats. Occurence of two fractions of mRNA, dissimilar in stability, is possible both in membrane-bound and in free polyribosomes from rat liver cells.
Download PDF:  
Citation:

Arbusov, V. A. (1979). mRNA degradation in membrane-bound and free polyribosomes in rat liver cells after exposure to actinomycin D and cycloheximide. Voprosy Meditsinskoi Khimii, 25(1), 62-67.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►