VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Extraction of cholesterol from vessel walls by surface-active agents and organic solvents

   
Lopukhin I.M., Berkovich M.A., Piatnitskiĭ N.N., Archakov A.I., Guliaev A.A., Sergienko V.I.
PubMed Id: 425374
Year: 1979  Volume: 25  Issue: 1  Pages: 75-77
Low concentrations (0.1--1.0%) of surface-active substances Tween-20, Triton X-100 and sodium deoxycholate were shown to extract 20--40% of cholesterol from dog vessel wall. Dioxane was effective at high concentrations (80--100%). As contrast to dioxane, ethanol extracted up to 20% of cholesterol at low concentrations (10--20%). The thickened intima of the atherosclerotic vessel is the significant barrier for the extraction of cholesterol.
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Lopukhin I.M., Berkovich M.A., Piatnitskiĭ N.N., Archakov A.I., Guliaev A.A., Sergienko V.I. (1979) Voprosy meditsinskoi khimii, 25(1), 75-77.
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