VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of hemodialysis on erythrocyte acetylcholinesterase and adenosine triphosphatase activity in chronic renal insufficiency

   
Kulikova A.I., Romanchuk L.A., Tugusheva F.A., Chuprasov V.B., Shostka G.D.
PubMed Id: 222070
Year: 1979  Volume: 25  Issue: 3  Pages: 268-272
Erythrocytes of patients with chronic kidney insufficiency exhibited high hexokinase activity as well as low activity of acetylcholinesterase and K+, Na+-dependent ATPase. The Km value of acetylcholinesterase for acetyl thiocholine was not altered in the reaction and the enzyme proved to be more resistant to heat denaturation. Therapy with permanent hemodialysis [8-10 hrs per day within some months] normalized K+, Na+-dependent ATPase activity and activated acetylcholinesterase. These effects may be considered as evidence for detoxication and normalization of metabolism. At the same time, high hexokinase activity and increased resistance of acetylcholinesterase to heat inactivation were maintained
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Kulikova, A. I., Romanchuk, L. A., Tugusheva, F. A., Chuprasov, V. B., Shostka, G. D. (1979). Effect of hemodialysis on erythrocyte acetylcholinesterase and adenosine triphosphatase activity in chronic renal insufficiency. Voprosy Meditsinskoi Khimii, 25(3), 268-272.
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