VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Physico-chemical aspects of mineralization of epiphyseal cartilage in endochondral osteogenesis

   
Peschansky V.S., Libinson G.S.
Year: 1979  Volume: 25  Issue: 3  Pages: 297-301
Mechanism of epiphysial cartilage mineralization is considered in terms of ion exchange concepts. Chondroitin-sulfate of matrix, which is a polyelectrolyte, served as a donor of calcium ions. Pericellular zone of matrix is considered as a semipermeable membrane. The energetic basis of the process is provided by intracellular glycogenolysis in chondrocytes, entering the zone of mineralization. High concentration of glucose in lacunas of chondrocytes led to osmotic transport of water from matrix to lacunas, causing an increase in concentration of ions in free volume of the matrix. Due to ion exchange release of calcium ions occurred from the phase of polyelectrolyte into the free volume, where the state of saturation was achieved and dicalcium phosphate CaHPO4 was precipitated. Stereologic studies of epiphysial cartilage, simulation experiments and calculations corroborate the mechanism of mineralization advanced.
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Peschansky V.S., Libinson G.S. (1979) Voprosy meditsinskoi khimii, 25(3), 297-301.
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