VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Importance of the initial monoamine oxidase activity for the development of the activating or inhibiting action of indolylhydrazides

   
Safrazbekian R.R., Sukasian R.S., Arzanunts E.M.
PubMed Id: 452498
Year: 1979  Volume: 25  Issue: 3  Pages: 311-314
Effects of beta-(2-methyl indolyl-3) propionic acid hydrazide and alpha-butyl-beta-(2-methyl-5-carboxy indolyl-3) propionic acid hydrazide on the activity of monoamine oxidase were studied in rat brain in vitro. The compounds activated distinctly serotonin deamination under conditions of the enzyme inhibition, caused by pretreatment with iproniazide. The activation occurred only in the samples, which were not inhibited with iproniazide. The treatment with iproniazide prevented any alterations in content of amines, caused by the compounds in the rat brain in vivo.
Download PDF:
Citation:

Safrazbekian, R. R., Sukasian, R. S., Arzanunts, E. M. (1979). Importance of the initial monoamine oxidase activity for the development of the activating or inhibiting action of indolylhydrazides. Voprosy meditsinskoi khimii, 25(3), 311-314.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)