VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of platinum and palladium compounds on mitochondrial enzymatic systems

   
Kolesova G.M., Zakharova I.A., Raĭkhman L.M., Moshkovskij I.Kh.
PubMed Id: 158883
Year: 1979  Volume: 25  Issue: 5  Pages: 537-540
Effect of platinum and palladium complexes on respiration and ATPase activity in bovine heart tissue as well as on respiration of submitochondrial particles was studied. The highest inhibitory activity was exhibited by the complexes of platinum and palladium with pi-ligands in internal coorhdinational sphere such as ethylene-C H4, norbornadiene-C7H8 and allyl-C3H5. The electron density at the central atom of the complex was not responsible for the inhibitory affect of platinum and palladium on mitochondria.
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Kolesova G.M., Zakharova I.A., Raĭkhman L.M., Moshkovskij I.Kh. (1979) Voprosy meditsinskoi khimii, 25(5), 537-540.
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