VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Blood serum enzymes in assessing the nature of the liver lesion and the effectiveness of chemotherapeutic actions in acrylonitrile poisoning

   
Ivanov V.V., Grishchenko D.A., Klimatskaia L.G.
PubMed Id: 516533
Year: 1979  Volume: 25  Issue: 6  Pages: 715-718
After intraperitoneal administration of acrylonitrile into rats, fructose monophosphate aldolase was found in blood serum, activity of butyryl cholinesterase was inhibited but activity of alkaline phosphatase was unaltered in rat blood serum; these data demonstrate the necro-bystrophic type impairment. Decrease in the hepatotoxic effect of acrylonitrile after preadministration of antioxidants appears to be a result of stimulation of lipid peroxidation, preventing the toxic effect of this industrially important substance.
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Ivanov V.V., Grishchenko D.A., Klimatskaia L.G. (1979) Voprosy meditsinskoi khimii, 25(6), 715-718.
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