VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice

   
Rozanov V.A.
PubMed Id: 7368625
Year: 1980  Volume: 26  Issue: 1  Pages: 42-46
Repeated administration of D-pantothenate Ca, D-homopantothenate Ca and pantethine at a dose of 150 mmole/kg of body weight (9 injections within 3 days) led to alterations in activity of GABA-shunt enzymes as well as in content of free amino acids in mouse brain. These alterations suggest that B3-vitamin preparations potentiate the regulating effect on gamma-aminobutyrate pathway, which shunts the alpha-ketoglutarate dehydrogenase reaction, depending on CoA content. The most distinct but short-term intesification of the GABA-shung was observed in treatment with homopantothenate containing GABA molecule. Pantothenate and pantethine caused similar alterations, consisting in activation of GABA production and in inhibition of its utilization; in this case pantethine was less effective. Pyridoxal phosphate activated GABA-shunt; this resulted in accelerated decrease in content of dicarboxylic amino acids and their amides.
Download PDF:  
Citation:

Rozanov, V. A. (1980). Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice. Voprosy Meditsinskoi Khimii, 26(1), 42-46.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►