VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

State of the monooxygenase enzymatic system during chronic diethylnitrosamine administration

   
Koliada A.Iu., Kobliakov V.A., Pan'shin O.A., Karamysheva A.F., Sennitskaia L.V.
PubMed Id: 7368626
Year: 1980  Volume: 26  Issue: 1  Pages: 47-51
Content of components and functional activity of monooxygenase enzyme system were studied in rat liver tissue during hepatocarcinogenesis produced by diethyl nitrosamine treatment. Content of cytochromes P-450 and b5, NADPH- NADH-cytochrome c reductase and demethylase activities as well as capacity to induce the monooxygenase enzyme system after administration of its inductors were not altered in chronic treatment with carcinogenic doses of diethyl nitrosamine. The higher doses of the amine were shown to reduce the content of the cytochromes in liver tissue.
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Koliada, A. Iu., Kobliakov, V. A., Pan'shin, O. A., Karamysheva, A. F., Sennitskaia, L. V. (1980). State of the monooxygenase enzymatic system during chronic diethylnitrosamine administration. Voprosy Meditsinskoi Khimii, 26(1), 47-51.
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