VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Phospholipid composition, lipid peroxidation, and activity of enzymes of hepatocyte organoids in alcoholic intoxication

   
Gruzdeva K.N., Antif'eva B.A., Eliseeva V.P., Musikhina S.V.
PubMed Id: 7192900
Year: 1980  Volume: 26  Issue: 2  Pages: 165-169
During chronic ethanol intoxication phase alterations in phospholipid composition and in intensity of oxidation were observed in liver microsomes and mitochondria. The oxidative reactions were most pronounced within the first 15 and 30 days as shown by an increase in activity of malate- and isocitrate dehydrogenases from the mitochondrial fraction. Administration of ethanol within 15 days was accompanied by an increase in content of phospholipids and their separate fractions both in microsomes and in mitochondria. In microsomes content of lipid peroxides was distinctly increased but content of free phospholipid fractions was most distinctly lowered within 90 days.
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Gruzdeva K.N., Antif'eva B.A., Eliseeva V.P., Musikhina S.V. (1980) Voprosy meditsinskoi khimii, 26(2), 165-169.
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