VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Specific glucocorticoid receptor in human liver cytosol

   
Golikov P.P., Bobkov A.I., Bobkova A.S., Eneleev R.Kh.
PubMed Id: 7456356
Year: 1980  Volume: 26  Issue: 2  Pages: 248-252
Specific cytoplasmic glucocorticoid receptors were isolated from biopsy material of liver tissue, obtained after operation of the patients with chronic impairment of bili ferous tract or from the patients with ulcerous disease of stomach within the stage of remission. The receptors isolated were saturated with dexamethasone; the dissociation constant value (Kdiss) of the complex was 1.37 10(-8) M and the amount of binding sites (n) was 1.96 10(-14) mol/mg of protein as calculated from a Scatchards' plot. Dexamethasone, corticosterol, hydrocortisone and deoxycorticosterol exhibited the highest competition for the binding sites of the receptor. The receptor of human liver studied was similar in its main properties to the dexamethasone-binding receptor from liver tissue of experimental animals.
Download PDF:  
Citation:

Golikov, P. P., Bobkov, A. I., Bobkova, A. S., Eneleev, R. Kh. (1980). Specific glucocorticoid receptor in human liver cytosol. Voprosy Meditsinskoi Khimii, 26(2), 248-252.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►