Mechanisms of regulating monoamine oxidase activity in different brain regions

Petrenko S.V., Balakleevskiĭ A.I.
PubMed Id: 7456358
Year: 1980  Volume: 26  Issue: 2  Pages: 264-270
Both in vitro and in vivo rates of oxidative deamination of 3H-dopamine (DA), 14C-tyramine (T), 14C-noradrenaline (NA), 3H-serotonine (S) and benzylamine (BA) by monoamine oxidases of homogenates of rat brain cortex, brain stem and basal ganglia were shown to be different either after administration of l-dihydroxyphenylalanine (l-DOPA) and of N1-d,l-seryl-N2/(2,3,4-trihydroxybenzyl) hydrazine (Ro 4-4602) or after their simultaneous administration into the animals. L-DOPA and Ro 4-4602, administered intraperitoneally at a dose of 50 mg/kg, did not affect distinctly the NA and S deamination in various parts of brain. Ro 4-4602 inhibited selectively the BA deamination in basal ganglia; simultaneous administration of the drug together with l-DOPA caused more pronounced inhibition of BA deamination; it decreased also the rate of deamination of DA and T in the ganglia. L-DOPA, Ro 4-4602 and their combination were especially effective at concentration 10(-4) M. These data characterize one of possible mechanisms of distinct antiparkinsonic action of these drugs. Ro 4-4602 was shown to inhibit the deamination of DA and S noncompetitively. L-DOPA (10(-5)--10(-4) M) activated selectively the DA deamination in brain mitochondria.
Download PDF:  

Petrenko, S. V., Balakleevskiĭ, A. I. (1980). Mechanisms of regulating monoamine oxidase activity in different brain regions. Voprosy Meditsinskoi Khimii, 26(2), 264-270.
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)