VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of adrenaline on the ATPase activity of rat liver plasma membranes

   
Ryskulova S.T., Ivashchenko A.T.
PubMed Id: 6256956
Year: 1980  Volume: 26  Issue: 3  Pages: 308-312
In vivo and in vitro adrenaline affected dissimilarly the activity of Na+, K+-, HCO3- and Mg2+-ATPases from plasmatic membranes of rat liver tissue. Inhibition of Na+, K+-ATPase and stimulation of Mg2+-ATPase activities were observed within 1, 24 and 48 hrs after subcutaneous administration of the hormone at a dose of 0.3 and 1.0 1.0 mg/kg of body weight; at the same time, HCO3- -ATPase activity was inhibited by adrenaline at a dose of 1.0 mg/kg and stimulated--at a dose of 0.3 mg/kg. After in vitro incubation of the plasmatic membranes with 5.45 10(-6)--10(-4) M of the hormone the activities of HCO3- - and Na+, K+-ATPases were inhibited but Mg2+-ATPase activity was not altered. The data obtained suggest that the ATPases, responsible for the active membrane transport of K+, Na+ and HCO3-, are highly sensitive to adrenaline.
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Ryskulova, S. T., Ivashchenko, A. T. (1980). Effect of adrenaline on the ATPase activity of rat liver plasma membranes. Voprosy Meditsinskoi Khimii, 26(3), 308-312.
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