VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Lecithin-cholesterol acyltransferase activity and lipid composition of high density lipoprotein subfractions in hyperalphalipoproteinemia

   
Ozerova I.N., Torkhovskaia T.I., Polesskiĭ V.A., Gerasimova E.N.
PubMed Id: 7456368
Year: 1980  Volume: 26  Issue: 3  Pages: 365-370
In blood plasma of men activity of lecithin-cholesterol acyl transferase /LCAT/ was elevated when the cholesterol concentration was increased in the fraction of high density lipoproteins /HDL/; the enzymatic activity was evaluated by the rate of 3H-cholesterol esterification in endogenous HDL. The phenomenon observed was accompanied by an increase in content of HDL2 subfraction: The content of free cholesterol was found to increase in the HDL2 fraction obtained from persons with hyper-alpha-lipoproteinemia. Analysis of the data obtained showed that LCAT activity was preferentially dependent on HDL3 cholesterol concentration in persons with low and middle content of HDL cholesterol, and--on HDL2 cholesterol concentration in patients with hyper-alpha-lipoproteinemia.
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Ozerova, I. N., Torkhovskaia, T. I., Polesskiĭ, V. A., Gerasimova, E. N. (1980). Lecithin-cholesterol acyltransferase activity and lipid composition of high density lipoprotein subfractions in hyperalphalipoproteinemia. Voprosy Meditsinskoi Khimii, 26(3), 365-370.
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