VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Activity of granulocyte proteinases and level of acid-stable proteinase inhibitors in the bronchial secretions of children with bronchopathies of different etiology

   
Oglobina O.G., Platonova L.V., Miasnikova L.V., Livshits M.B., Paskhina T.S.
PubMed Id: 7006205
Year: 1980  Volume: 26  Issue: 3  Pages: 387-392
Activities of elastase- and trypsin-like proteinases from granulocytes as well as content of their acid-stable inhibitors were studied in 80 samples of the bronchial secretory products obtained from 34 children from 4 to 15 years old suffering from various forms of bronchopulmonary pathology/primary chronic pneumonia, Cartagener's syndrom, mucoviscidosis, pulmonary malformations. Normal bronchial secretory products were characterized by high content of the acid-stable inhibitors as well as by absence of the granulocytic proteinases activity. Development of inflammatory impairments in bronchi was accompanied by 2-3-fold decrease in content of the inhibitors with simultaneous increase in the enzymatic activity. The data obtained suggest that the relationship between activity of granulocytic proteinases and content of acid-stable inhibitors in bronchial secretory products might be considered as an important index of inflammatory processes in bronchi. De novo synthesis of acid-stable inhibitors in lungs appears to be decreased in the course of development of inflammation.
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Oglobina, O. G., Platonova, L. V., Miasnikova, L. V., Livshits, M. B., Paskhina, T. S. (1980). Activity of granulocyte proteinases and level of acid-stable proteinase inhibitors in the bronchial secretions of children with bronchopathies of different etiology. Voprosy Meditsinskoi Khimii, 26(3), 387-392.
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