VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Collagen metabolism indices, and plasma concentrations of lipids, cyclic 3',5'-AMP, and certain hormones in 40-59-year-old men

   
Bazanov E.A., Gerasimova E.N., Ozerova I.N., Bezhanian M.V., Suchkova S.N.
PubMed Id: 6256961
Year: 1980  Volume: 26  Issue: 4  Pages: 464-470
Concentrations of protein-bound hydroxyprolin, free hydroxyproline, cholesterol, alpha-cholesterol, triglycerides, testosterone, estradiol, insuline and 3',5'-cAMP were estimated in blood plasma of 40-59 years old men. The persons thus examined were divided into three groups depending on the content of protein-bound hydroxyproline. Only in blood plasma of persons with low concentration of the protein-bound hydroxyproline a direct correlation was found between cAMP and testosterone, cAMP and alpha-cholesterol, between cAMP and the ratio of the cholesterol from atherogenous lipoproteins to the cholesterol from alpha-lipoproteins, as well as reciprocal correlation--between cAMP and insulin. The increase of protein-bound hydroxyproline concentration and the decrease of cAMP content in blood plasma might be related to proliferation of smooth muscle cells in the vessel wall, dependent, first, on alteration in the ratio of lipoproteins of various density in blood plasma and, second, on alteration in the hormone concentration in blood and tissues.
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Bazanov, E. A., Gerasimova, E. N., Ozerova, I. N., Bezhanian, M. V., Suchkova, S. N. (1980). Collagen metabolism indices, and plasma concentrations of lipids, cyclic 3',5'-AMP, and certain hormones in 40-59-year-old men. Voprosy Meditsinskoi Khimii, 26(4), 464-470.
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