An interaction was studied between various lipoproteins (low density lipoproteins--LDL, very low density lipoproteins--LVDL, subfractions of high density lipoproteins--HDL2, HDL3) and artificial bilayer lipid membranes (BLM) produced from oxydized cholesterol. The lipoproteins increased from 100 to 1000-fold the conductivity of BLM for cations Na+, K+, Ca2+, but not for anions. Critical concentrations of the lipoproteins at which their modifying effect was manifested, correlated reciprocally with the size of the lipoprotein particles; they were arranged as follows: VLDL < LDL < HDL2 < HDL3. Decrease in the pH value lowered these critical concentrations. Addition of Ca2+ into the solution decreased the critical concentrations of VLDL and LDL from 2- to 4-fold as well as of HDL2 and HDL3--from 9- to 12-fold. The electrostatic power appears to be important in interaction between the lipoproteins and bilayer lipid membranes.
Martseniuk O.V. et al. Effect of human plasma lipoproteins on ionic conductivity of lipid bilayer membranes // Voprosy meditsinskoi khimii. - 1980. - V. 26. -N 4. - P. 484-489.
Martseniuk O.V. et al., "Effect of human plasma lipoproteins on ionic conductivity of lipid bilayer membranes." Voprosy meditsinskoi khimii 26.4 (1980): 484-489.
Martseniuk, O. V., Perova, N. V., Gerasimova, E. N., Tverdislov, V. A., El-Karadagi, S. S. (1980). Effect of human plasma lipoproteins on ionic conductivity of lipid bilayer membranes. Voprosy meditsinskoi khimii, 26(4), 484-489.