VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Mitochondrial and lysosomal membrane stability following administration of excessive doses of vitamin A in vivo

   
Kon' I.Ia., Temirkulova R.S., Shirina L.I.
PubMed Id: 6779419
Year: 1980  Volume: 26  Issue: 4  Pages: 528-534
Stability of mitochondrial and lysosomal membranes was studied in growing rats under conditions of hypervitaminosis A. The membrane stability was evaluated by the rate of solubilization of marker mitochondrial enzyme--malate dehydrogenase, and of lysosomal enzyme--beta-galactosidase, using incubation of the isolated organelles with gradually increasing concentrations of Triton X-100. High doses of vitamin A did not affect the total activity of the enzymes studied but distinctly increased the rate of malate dehydrogenase and beta-galactosidase solubilization, caused by Triton X-100, as compared with controls. This suggests the increase in sensitivity of the organelle membranes to the effect of Triton X-100 in the hypervitaminosis A, which is apparently related to pronounced impairment of the membrane structure.
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Kon', I. Ia., Temirkulova, R. S., Shirina, L. I. (1980). Mitochondrial and lysosomal membrane stability following administration of excessive doses of vitamin A in vivo. Voprosy Meditsinskoi Khimii, 26(4), 528-534.
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