VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Mechanism of the activating action of noradrenaline on rat cerebral cortex Na, K-ATPase

   
Pikulev A.T., Shcherban' A.I.
PubMed Id: 6252690
Year: 1980  Volume: 26  Issue: 5  Pages: 671-673
Effect of noradrenaline on kinetics of Na, K-ATPase activation in rat brain cortex was studied using ATP as a substrate and Na+ or K+ ions as cofactors. Noradrenaline (5 x 10(-5) M) increased the activating effect of ATP and Mg2+ as well as that of Na+ and K+. In presence of ATP and Mg2+ the hormone activated ATPase by the mixed type, and in response to Na+, K+ addition--by the non-competitive type. Noradrenaline appears to cause the conformational alterations in Na, K-ATPase molecule, which change the kinetics of the enzyme activation by ATP and the ions.
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Pikulev, A. T., Shcherban', A. I. (1980). Mechanism of the activating action of noradrenaline on rat cerebral cortex Na, K-ATPase. Voprosy Meditsinskoi Khimii, 26(5), 671-673.
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