VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Enzymatic activity of glycoprotein catabolism in the organs of rats with hyper- and hypovitaminosis A

   
Kon' I.Ia., Valiakina T.I., Temirkulova R.S., Lavrova N.V.
PubMed Id: 6775413
Year: 1980  Volume: 26  Issue: 5  Pages: 704-711
Activities of glycosidases neuromanidase, alpha-L-fucosidase, beta-galactosidase and beta-N-acetylglucosaminidase were studied in rat small intestine and liver tissue under conditions of hyper- and hypovitaminosis A. Both excessive and insufficient administrations of vitamin A were accompanied by distinct alterations in activity of the enzymes studied in small intestine and (although less distinct) in liver tissue. The most significant dependence on the presence of vitamin A exhibited beta-galactosidase and especially alpha-L-fucosidase, activity of which was decreased in hypervitaminosis and increased in hypovitaminosis A. Activity of neuraminidase was usually slightly altered but its marked activation was noted in liver tissue under conditions of hypervitaminosis A. Vitamin A appears to participate in allosteric control of the glycosidase activity in small intestine and in catabolism of glycoproteins. The alterations of the enzymatic activity found in hyper- and hypovitaminosis A might be responsible for changes in composition of membrane glycoproteins and, hence, for the typical for vitamin A disbalance impairments in cellular growth and differentiation.
Download PDF:  
Citation:

Kon', I. Ia., Valiakina, T. I., Temirkulova, R. S., Lavrova, N. V. (1980). Enzymatic activity of glycoprotein catabolism in the organs of rats with hyper- and hypovitaminosis A. Voprosy Meditsinskoi Khimii, 26(5), 704-711.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►