VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Decrease in the activity of cerebral gamma-aminobutyric acid metabolism enzymes under the influence of kynurenines possessing convulsive activity

   
Lapin I.P., Nikitina Z.S., Sytinskiĭ I.A.
PubMed Id: 7467203
Year: 1981  Volume: 27  Issue: 1  Pages: 27-30
Content of gamma-aminobutyric acid (GABA) was unaltered in mouse brain and cerebellum after administration of D,L-kynurenine (50 mcg), quinolinic acid (5 mcg) and nicotinic acid (50 mcg) into brain ventricles. At the same time, after administration of kinurenine, quinolinic acid and nicotinic acid activity of GABA-transaminase in brain was decreased by 39%, 40% and 48, respectively; activity of glutamate decarboxylase was decreased by 27% and 36%, respectively, in this case nicotinic acid affected only slightly. Strong clonic convulsions occurred in 60% of mice after administration of kynurenine and quinolinic acid and only in 7% of mice after treatment with nicotinic acid. Deceleration in the GABA turnover and the subsequent weakening of the brain inhibitory systems were apparently essential in development of convulsions caused by the kynurenines.
Download PDF:  
Citation:

Lapin, I. P., Nikitina, Z. S., Sytinskiĭ, I. A. (1981). Decrease in the activity of cerebral gamma-aminobutyric acid metabolism enzymes under the influence of kynurenines possessing convulsive activity. Voprosy Meditsinskoi Khimii, 27(1), 27-30.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►