VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Biotransformation of ftorafur

   
Kozhukhov A.N.
PubMed Id: 6792775
Year: 1981  Volume: 27  Issue: 2  Pages: 243-247
Biotransformation of ftorafir (FT) was studied using 2-14C-ftorafur and 2;5'-14C-ftorafur. Both pyrimidine and tetrahydrofurane moieties of the FT underwent degradation to CO2 in rats. The cleavage of the pseudoglycosidic bonds C-N and formation of 5-fluorouracil was one of the steps of the FT metabolism that limited the velocity of the whole biotransformation process. Liver tissue NADPH-linked monooxygenating system was shown to participate in the process. The data obtained suggest that the role of enzymes involved in metabolism of nucleic acids was not significant in the FT metabolism under the conditions studied in vivo.
Download PDF:  
Citation:

Kozhukhov, A. N. (1981). Biotransformation of ftorafur. Voprosy Meditsinskoi Khimii, 27(2), 243-247.
References
 1984 (vol 30)
 1983 (vol 29)
 1982 (vol 28)
 1981 (vol 27)
 1980 (vol 26)
 1979 (vol 25)
 1978 (vol 24)
 1977 (vol 23)
 1976 (vol 22)
 1975 (vol 21)
 1974 (vol 20)
 1973 (vol 19)
 1972 (vol 18)
 1971 (vol 17)
 1970 (vol 16)
 1969 (vol 15)
 1968 (vol 14)
 1967 (vol 13)
 1966 (vol 12)
 1965 (vol 11)
◄        ►