VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital

   
Chistiakov V.V., Prikhod'ko A.Z.
PubMed Id: 7281573
Year: 1981  Volume: 27  Issue: 3  Pages: 340-342
A preadministration of testosterone propionate into rat females within 8 days caused an increase in the inducing effect of phenobarbital (after its single injection) on the content of cytochrome P-450 in liver tissue. The administration of testosterone did not affect the content of the enzyme in liver tissue. A shown in the experiments on phenobarbital induction of the enzyme as a function of duration of testosterone administration, two maximal peaks, within 1 and 8 days, were observed after preadministration of the hormone. The hormone influenced mainly on the rate of the increase in cytochrome P-450 content but not on degree of its induction.
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Chistiakov, V. V., Prikhod'ko, A. Z. (1981). Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital. Voprosy Meditsinskoi Khimii, 27(3), 340-342.
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