VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Effect of L-ascorbic and D-isoascorbic acids on induced formation of tyrosine aminotransferase in rat liver

   
Levchuk A.A., Bukin I.V., Smirnova K.D., Raushenbakh M.O., Rubtsov I.A.
PubMed Id: 6117152
Year: 1981  Volume: 27  Issue: 4  Pages: 500-503
Administration of ascorbic acid at moderate doses/0.05-0.1 g per kg of body mass/was shown to induce tyrosine transaminase in liver tissue of intact rats. The enzyme induction depended on the state of adrenal glands and was inhibited by actinomycin D. As distinct from the native form of L-ascorbic acid moderate doses of D-isoascorbic acid did not induce the enzyme in rat liver tissue; these data suggest the relative biological inactivity of D-isoascorbic acid.
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Levchuk A.A., Bukin I.V., Smirnova K.D., Raushenbakh M.O., Rubtsov I.A. (1981) Voprosy meditsinskoi khimii, 27(4), 500-503.
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