VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Insulin-heparin complex, its physiological properties

   
Kudriashov B.A., Pytel' Iu.A., Liapina L.A., Baskakova G.M.
PubMed Id: 7027617
Year: 1981  Volume: 27  Issue: 4  Pages: 547-552
An insulin-heparin complex was obtained in vitro. The hypoglycemic effect of insulin, included into this complex as compared with free insulin, was increased more than 2-fold when it was tested in animals with stable alloxane diabetes. Contrary to insulin, administration of the insulin-heparin complex increased the anticoagulation properties of blood and exhibited the non-enzymatic fibrinolytic activity towards the unstabilized fibrin both in presence or in absence of inhibitors of fibrinolysis, caused by plasmin.
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Kudriashov, B. A., Pytel', Iu. A., Liapina, L. A., Baskakova, G. M. (1981). Insulin-heparin complex, its physiological properties. Voprosy Meditsinskoi Khimii, 27(4), 547-552.
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